Evaluation of the JIA treatment with adalimumab in ukraine

Introduction The prevalence of juvenile idiopathic arthritis (JIA) in Ukrainian children’s population is 4.1 per 10 000 and the total number of children with JIA is about 3000. JIA couldn’t be considered as a benign disease, because very often it results in a sustainable disability. Previously was shown, that early diagnostic and treatment lead to better results. TNF is a key proinflammatory cytokine in the pathogenesis of oligoarthicular and polyarthicular forms of JIA. TNF-inhibition can prevent irreversible structural joint damage. In children with methotrexate failure the after treatment with biologic agents reduces the number of disease flares by 54%. Adalimumab, the anti-TNFalpha recombinant human monoclonal antibody, recently had been approved in Ukraine for the treatment of polyarthicular juvenil arthritis in children and was included to the state JIA treatment funding programme.